› 3q4f

X-ray diffraction
5.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171682 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Non-homologous end-joining factor 1 Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 230 amino acids
Theoretical weight: 26.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9Q4 (Residues: 1-224; Coverage: 75%)
Gene names: NHEJ1, XLF
Sequence domains: XLF-Cernunnos, XRcc4-like factor, NHEJ component
DNA repair protein XRCC4 Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 186 amino acids
Theoretical weight: 21.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13426 (Residues: 1-157; Coverage: 47%)
Gene name: XRCC4
Sequence domains: DNA double-strand break repair and V(D)J recombination protein XRCC4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P6522
Unit cell:
a: 103.86Å b: 103.86Å c: 855.22Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.252 0.25 0.309
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Repair of double-strand breaks by end joining.
Chiruvella et al. (2013)
29 more

4 mentions without citation

Targeting protein-protein interactions in the DNA damage response pathways for cancer chemotherapy.
McPherson et al. (2021)
3 more