› 3q93

X-ray diffraction
1.8Å resolution

Crystal Structure of Human 8-oxo-dGTPase (MTH1)

Released:
DOI: 10.2210/pdb3q93/pdb
PDB entry 3q93 coloured by chain, front view.
PDB entry 3q93 coloured by chain, side view.
PDB entry 3q93 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Siponen MI, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Ekblad T, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kol S, Kotenyova T, Kouznetsova E, Moche M, Nyman T, Persson C, Schuler H, Schutz P, Thorsell AG, Van Der Berg S, Wahlberg E, Weigelt J, Welin M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidized purine nucleoside triphosphate hydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 20.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P36639 (Residues: 1-156; Coverage: 100%)
Gene names: MTH1, NUDT1
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

3 bound ligands:
Ligand SO4 5 x SO4
Ligand IMD 1 x IMD
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 59.544Å b: 67.681Å c: 82.678Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.233
Expression system: Escherichia coli BL21(DE3)

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