› 3qa3

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210502 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody Light chain Chains: A, C, F, J
Molecule details ›
Chains: A, C, F, J
Length: 220 amino acids
Theoretical weight: 24.46 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Antibody Heavy chain Chains: B, D, H, K
Molecule details ›
Chains: B, D, H, K
Length: 224 amino acids
Theoretical weight: 24.04 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Integrin alpha-M Chains: E, G, I, L
Molecule details ›
Chains: E, G, I, L
Length: 190 amino acids
Theoretical weight: 21.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11215 (Residues: 148-337; Coverage: 17%)
Gene names: CD11B, CR3A, ITGAM
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

3 bound ligands:
Ligand EDO 8 x EDO
Ligand GOL 5 x GOL
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 82.604Å b: 158.346Å c: 233.319Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.224
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Integrins as Therapeutic Targets: Successes and Cancers.
Raab-Westphal et al. (2017)
5 more

2 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
1 more