3qaz

X-ray diffraction
3.8Å resolution

IL-2 mutant D10 ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-147094 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-2 Chains: A, D, G, J, M, P, S, V, Y, b, e, h
Molecule details ›
Chains: A, D, G, J, M, P, S, V, Y, b, e, h
Length: 136 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P60568 (Residues: 21-153; Coverage: 100%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;
Interleukin-2 receptor subunit beta Chains: B, E, H, K, N, Q, T, W, Z, c, f, i
Molecule details ›
Chains: B, E, H, K, N, Q, T, W, Z, c, f, i
Length: 217 amino acids
Theoretical weight: 25.04 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P14784 (Residues: 24-240; Coverage: 41%)
Gene names: IL15RB, IL2RB
Sequence domains: Interleukin-2 receptor subunit beta N-terminal domain 1
Structure domains: Immunoglobulins
Cytokine receptor common subunit gamma Chains: C, F, I, L, O, R, U, X, a, d, g, j
Molecule details ›
Chains: C, F, I, L, O, R, U, X, a, d, g, j
Length: 202 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P31785 (Residues: 56-254; Coverage: 57%)
Gene name: IL2RG
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P1
Unit cell:
a: 118.226Å b: 118.099Å c: 236.115Å
α: 99.86° β: 99.86° γ: 99.74°
R-values:
R R work R free
0.292 0.291 0.344
Expression system: Trichoplusia ni