› 3qbr

X-ray diffraction
2.6Å resolution

BakBH3 in complex with sjA

Released:
DOI: 10.2210/pdb3qbr/pdb
PDB entry 3qbr coloured by chain, front view.
PDB entry 3qbr coloured by chain, side view.
PDB entry 3qbr coloured by chain, top view.
Source organisms:
Primary publication:
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Lee EF, Clarke OB, Evangelista M, Feng Z, Speed TP, Tchoubrieva EB, Strasser A, Kalinna BH, Colman PM, Fairlie WD
Proc Natl Acad Sci U S A 108 6999-7003 (2011)
PMID: 21444803

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172522 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2 Bcl-2 homology region 1-3 domain-containing protein Chains: A, X
Molecule details ›
Chains: A, X
Length: 179 amino acids
Theoretical weight: 20.48 KDa
Source organism: Schistosoma japonicum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5BWX6 (Residues: 21-189; Coverage: 74%)
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chains: B, Y
Molecule details ›
Chains: B, Y
Length: 34 amino acids
Theoretical weight: 3.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16611 (Residues: 63-96; Coverage: 16%)
Gene names: BAK, BAK1, BCL2L7, CDN1

Ligands and Environments

1 bound ligand:
Ligand NHE 1 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I23
Unit cell:
a: 148.625Å b: 148.625Å c: 148.625Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.171 0.234
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

11 review citations

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Czabotar et al. (2014)
10 more

1 mention without citation

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Lee et al. (2011)