3qct

X-ray diffraction
2.15Å resolution

Crystal structure of the humanized apo LT3015 anti-lysophosphatidic acid antibody Fab fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-134636 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 24.04 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q6N089 (Residues: 20-243; Coverage: 49%)
Gene name: DKFZp686P15220
Sequence domains:
Structure domains: Immunoglobulins
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 23.84 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01834 (Residues: 1-106; Coverage: 99%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P43212
Unit cell:
a: 84.523Å b: 84.523Å c: 145.276Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.287
Expression system: Cricetulus griseus