› 3qf2

X-ray diffraction
1.7Å resolution

Crystal structure of NALP3 PYD

Released:
DOI: 10.2210/pdb3qf2/pdb
PDB entry 3qf2 coloured by chain, front view.
PDB entry 3qf2 coloured by chain, side view.
PDB entry 3qf2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly.
Bae JY, Park HH
J Biol Chem 286 39528-36 (2011)
PMID: 21880711

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96P20 (Residues: 3-112; Coverage: 11%)
Gene names: C1orf7, CIAS1, NALP3, NLRP3, PYPAF1
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P21
Unit cell:
a: 42.032Å b: 60.04Å c: 51.529Å
α: 90° β: 107.62° γ: 90°
R-values:
R R work R free
0.212 0.183 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

51 review citations

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
Abderrazak et al. (2015)
50 more

35 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
34 more