3qt2

X-ray diffraction
2.55Å resolution

Structure of a cytokine ligand-receptor complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-138518 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-5 receptor subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01344 (Residues: 20-332; Coverage: 78%)
Gene names: IL5R, IL5RA
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins
Interleukin-5 Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 117 amino acids
Theoretical weight: 13.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05113 (Residues: 19-134; Coverage: 100%)
Gene name: IL5
Sequence domains: Interleukin 5
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 85.084Å b: 61.633Å c: 142.113Å
α: 90° β: 99.49° γ: 90°
R-values:
R R work R free
0.21 0.207 0.264
Expression system: Escherichia coli