› 3qte

X-ray diffraction
1.95Å resolution

Crystal structure of human alpha-defensin 6 (H27W mutant)

Released:
DOI: 10.2210/pdb3qte/pdb
PDB entry 3qte coloured by chain, front view.
PDB entry 3qte coloured by chain, side view.
PDB entry 3qte coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL
Science 337 477-81 (2012)
PMID: 22722251

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169588 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin-6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 32 amino acids
Theoretical weight: 3.77 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01524 (Residues: 69-100; Coverage: 40%)
Gene names: DEF6, DEFA6
Sequence domains: Mammalian defensin

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 33.774Å b: 32.675Å c: 54.005Å
α: 90° β: 108.35° γ: 90°
R-values:
R R work R free
0.195 0.192 0.247
Expression system: Not provided

Quick links

Citations

86 review citations

Microbiota-mediated colonization resistance against intestinal pathogens.
Buffie et al. (2013)
85 more

2 mentions without citation

Molecular basis for self-assembly of a human host-defense peptide that entraps bacterial pathogens.
Chairatana et al. (2014)
1 more