› 3qye

X-ray diffraction
2.2Å resolution

Crystal Structure of Human TBC1D1 RabGAP domain

Released:
DOI: 10.2210/pdb3qye/pdb
PDB entry 3qye coloured by chain, front view.
PDB entry 3qye coloured by chain, side view.
PDB entry 3qye coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Park SY, Jin W, Woo JR, Shoelson SE
J Biol Chem 286 18130-8 (2011)
PMID: 21454505

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 38.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86TI0 (Residues: 746-1072; Coverage: 28%)
Gene names: KIAA1108, TBC1D1
Sequence domains: Rab-GTPase-TBC domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A, NSLS BEAMLINE X12C
Spacegroup: P43212
Unit cell:
a: 117.36Å b: 117.36Å c: 141.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Molecular control of Rab activity by GEFs, GAPs and GDI.
Müller et al. (2018)
15 other articles

4 mentions without citation

Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Park et al. (2011)
3 more