› 3r08

X-ray diffraction
4.1Å resolution

Crystal structure of mouse cd3epsilon in complex with antibody 2C11 Fab

Released:
DOI: 10.2210/pdb3r08/pdb
PDB entry 3r08 coloured by chain, front view.
PDB entry 3r08 coloured by chain, side view.
PDB entry 3r08 coloured by chain, top view.
Source organism: Cricetulus migratorius
Primary publication:
T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.
Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ
J Biol Chem 287 13324-35 (2012)
PMID: 22262845

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210863 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Mouse anti-mouse CD3epsilon antibody 2C11 light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.65 KDa
Source organism: Cricetulus migratorius
Expression system: Not provided
Mouse anti-mouse CD3epsilon antibody 2C11 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 216 amino acids
Theoretical weight: 23.15 KDa
Source organism: Cricetulus migratorius
Expression system: Not provided
T-cell surface glycoprotein CD3 epsilon chain Chain: E
Molecule details ›
Chain: E
Length: 82 amino acids
Theoretical weight: 9.46 KDa
Source organism: Cricetulus migratorius
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P22646 (Residues: 22-100; Coverage: 47%)
Gene name: Cd3e
Sequence domains: Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I4132
Unit cell:
a: 263.177Å b: 263.177Å c: 263.177Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.277
Expression systems:
  • Not provided
  • Cricetulus griseus

Quick links

Citations

5 review citations

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.
Wang et al. (2012)
4 more

1 mention without citation

T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.
Fernandes et al. (2012)