› 3r0n

X-ray diffraction
1.3Å resolution

Crystal Structure of the Immunoglobulin variable domain of Nectin-2

Released:
DOI: 10.2210/pdb3r0n/pdb
PDB entry 3r0n coloured by chain, front view.
PDB entry 3r0n coloured by chain, side view.
PDB entry 3r0n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.
Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC
Proc Natl Acad Sci U S A 109 14836-40 (2012)
PMID: 22927415

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187722 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nectin-2 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92692 (Residues: 32-158; Coverage: 25%)
Gene names: HVEB, NECTIN2, PRR2, PVRL2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P41212
Unit cell:
a: 57.964Å b: 57.964Å c: 67.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.173
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity.
Samanta et al. (2015)
10 more

9 mentions without citation

Potential mechanisms and implications for the formation of tau oligomeric strains.
Gerson et al. (2016)
8 more