› 3r1n

X-ray diffraction
2.09Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-activated protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 36.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16644 (Residues: 33-349; Coverage: 83%)
Gene name: MAPKAPK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 05B 1 x 05B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 84.13Å b: 75.79Å c: 61.34Å
α: 90° β: 108.01° γ: 90°
R-values:
R R work R free
0.216 0.214 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials.
Fiore et al. (2016)
7 other articles

4 mentions without citation

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.
Vasili et al. (2019)
3 more