› 3r62

X-ray diffraction
1.52Å resolution

Structure of complement regulator Factor H mutant, T1184R.

Released:
DOI: 10.2210/pdb3r62/pdb
PDB entry 3r62 coloured by chain, front view.
PDB entry 3r62 coloured by chain, side view.
PDB entry 3r62 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic determination of the disease-associated T1184R variant of the complement Factor H.
Morgan HP, Jiang J, Herbert AP, Kavanagh D, Uhran D, Barlow PN, Hannan JP
Acta Crystallogr. D Biol. Crystallogr. 67 593-600 (2011)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.83 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1107-1231; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 36.886Å b: 52.84Å c: 142.628Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.208
Expression system: Komagataella pastoris

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