› 3r6b

X-ray diffraction
2.4Å resolution

Crystal Structure of Thrombospondin-1 TSR Domains 2 and 3

Released:
DOI: 10.2210/pdb3r6b/pdb
PDB entry 3r6b coloured by chain, front view.
PDB entry 3r6b coloured by chain, side view.
PDB entry 3r6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system.
Klenotic PA, Page RC, Misra S, Silverstein RL
Protein Expr Purif 80 253-9 (2011)
PMID: 21821127

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombospondin-1 Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 16.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07996 (Residues: 434-547; Coverage: 10%)
Gene names: THBS1, TSP, TSP1
Sequence domains: Thrombospondin type 1 domain
Structure domains: Thrombospondin type-1 (TSP1) repeat

Ligands and Environments

1 bound ligand:
Ligand EDO 8 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 66.364Å b: 84.817Å c: 60.707Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.235 0.273
Expression system: Escherichia coli

Quick links

Citations

10 citation in other articles

Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.
Zhao et al. (2014)
9 more

9 mentions without citation

Phosphatidylserine receptors: enhancers of enveloped virus entry and infection.
Moller-Tank et al. (2014)
8 more