› 3r6n

X-ray diffraction
2.95Å resolution

Crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain

Released:
DOI: 10.2210/pdb3r6n/pdb
PDB entry 3r6n coloured by chain, front view.
PDB entry 3r6n coloured by chain, side view.
PDB entry 3r6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.
Choi HJ, Weis WI
J Mol Biol 409 800-12 (2011)
PMID: 21536047

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Desmoplakin Chains: A, B
Molecule details ›
Chains: A, B
Length: 450 amino acids
Theoretical weight: 53.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P15924 (Residues: 178-627; Coverage: 16%)
Gene name: DSP
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand D1D 2 x D1D
Ligand DTT 2 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 157.52Å b: 82.52Å c: 139.98Å
α: 90° β: 125.54° γ: 90°
R-values:
R R work R free
0.221 0.216 0.265
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Spectraplakins: master orchestrators of cytoskeletal dynamics.
Suozzi et al. (2012)
10 more

12 mentions without citation

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
11 more