› 3r8i

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand XCX 1 x XCX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 93.589Å b: 62.398Å c: 118.392Å
α: 90° β: 102.11° γ: 90°
R-values:
R R work R free
0.252 0.252 0.285
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications.
Serafini et al. (2021)
16 other articles

2 mentions without citation

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARĪ³.
Shang et al. (2018)
1 more