› 3rbg

X-ray diffraction
2.3Å resolution

Crystal structure analysis of Class-I MHC restricted T-cell associated molecule

Released:
DOI: 10.2210/pdb3rbg/pdb
PDB entry 3rbg coloured by chain, front view.
PDB entry 3rbg coloured by chain, side view.
PDB entry 3rbg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional classification of immune regulatory proteins.
Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A
Structure 21 766-76 (2013)
PMID: 23583034

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132006 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic and regulatory T-cell molecule Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 124 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O95727 (Residues: 18-117; Coverage: 27%)
Gene name: CRTAM
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand PO4 4 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2221
Unit cell:
a: 116.02Å b: 116.291Å c: 79.018Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.234
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Combination cancer immunotherapy and new immunomodulatory targets.
Mahoney et al. (2015)
3 more

5 mentions without citation

Functional classification of immune regulatory proteins.
Rubinstein et al. (2013)
4 more