Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136960 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C-terminal core protein
Molecule details ›
Chains: A, C
Length: 166 amino acids
Theoretical weight: 19.14 KDa
Source organism: HIV-1 M:B_ARV2/SF2
Expression system: Escherichia coli
UniProt:
Sequence domains: Negative factor, (F-Protein) or Nef
Structure domains: Nef Regulatory Factor
Length: 166 amino acids
Theoretical weight: 19.14 KDa
Source organism: HIV-1 M:B_ARV2/SF2
Expression system: Escherichia coli
UniProt:
- Canonical:
P03407 (Residues: 45-210; Coverage: 79%)
Sequence domains: Negative factor, (F-Protein) or Nef
Structure domains: Nef Regulatory Factor
Tyrosine-protein kinase HCK
Molecule details ›
Chains: B, D
Length: 90 amino acids
Theoretical weight: 10.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Length: 90 amino acids
Theoretical weight: 10.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P08631 (Residues: 79-138; Coverage: 11%)
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X10SA
Spacegroup:
P61
Expression system: Escherichia coli
