› 3rfe

X-ray diffraction
1.24Å resolution

Crystal structure of glycoprotein GPIb ectodomain

Released:
DOI: 10.2210/pdb3rfe/pdb
PDB entry 3rfe coloured by chain, front view.
PDB entry 3rfe coloured by chain, side view.
PDB entry 3rfe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J
Blood 118 5292-301 (2011)
PMID: 21908432

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet glycoprotein Ib beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P13224 (Residues: 26-146; Coverage: 67%)
Gene name: GP1BB
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand MG 2 x MG
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 61.506Å b: 34.764Å c: 71.532Å
α: 90° β: 92.15° γ: 90°
R-values:
R R work R free
0.202 0.201 0.224
Expression system: Cricetulus griseus

Quick links

Citations

8 review citations

von Willebrand factor, Jedi knight of the bloodstream.
Springer TA. (2014)
7 more

3 mentions without citation

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
McEwan et al. (2011)
2 more