› 3rjd

X-ray diffraction
2.65Å resolution

Crystal structure of Fc RI and its implication to high affinity immunoglobulin G binding

Released:
DOI: 10.2210/pdb3rjd/pdb
PDB entry 3rjd coloured by chain, front view.
PDB entry 3rjd coloured by chain, side view.
PDB entry 3rjd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding.
Lu J, Ellsworth JL, Hamacher N, Oak SW, Sun PD
J Biol Chem 286 40608-13 (2011)
PMID: 21965667

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
High affinity immunoglobulin gamma Fc receptor I Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 29.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P12314 (Residues: 21-282; Coverage: 73%)
Gene names: FCG1, FCGR1, FCGR1A, IGFR1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand P33 1 x P33
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 92.828Å b: 92.828Å c: 90.763Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.248 0.276
Expression system: Cricetulus griseus

Quick links

Citations

13 review citations

Properties of mouse and human IgG receptors and their contribution to disease models.
Bruhns P. (2012)
12 more

20 mentions without citation

A perspective on the structure and receptor binding properties of immunoglobulin G Fc.
Hanson et al. (2015)
19 more