› 3rjo

X-ray diffraction
2.3Å resolution

Crystal Structure of ERAP1 Peptide Binding Domain

Released:
DOI: 10.2210/pdb3rjo/pdb
PDB entry 3rjo coloured by chain, front view.
PDB entry 3rjo coloured by chain, side view.
PDB entry 3rjo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1.
Gandhi A, Lakshminarasimhan D, Sun Y, Guo HC
Sci Rep 1 186 (2011)
PMID: 22355701

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192727 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmic reticulum aminopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 48.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NZ08 (Residues: 529-941; Coverage: 44%)
Gene names: APPILS, ARTS1, ERAP1, KIAA0525, UNQ584/PRO1154
Sequence domains: ERAP1-like C-terminal domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 63.84Å b: 67.31Å c: 65.92Å
α: 90° β: 110.25° γ: 90°
R-values:
R R work R free
0.196 0.192 0.262
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.
Alvarez-Navarro et al. (2014)
5 more

5 mentions without citation

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families.
Pascual Alonso et al. (2023)
4 more