› 3rk6

X-ray diffraction
2Å resolution

Crystal structure of the middle domain of human Paip1

Released:
DOI: 10.2210/pdb3rk6/pdb
PDB entry 3rk6 coloured by chain, front view.
PDB entry 3rk6 coloured by chain, side view.
PDB entry 3rk6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1.
Lei J, Mesters JR, von Brunn A, Hilgenfeld R
Biochem Biophys Res Commun 408 680-5 (2011)
PMID: 21539810

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190469 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyadenylate-binding protein-interacting protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 234 amino acids
Theoretical weight: 26.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H074 (Residues: 157-373; Coverage: 45%)
Gene name: PAIP1
Sequence domains: MIF4G domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 58.61Å b: 76.05Å c: 62.42Å
α: 90° β: 96.47° γ: 90°
R-values:
R R work R free
0.192 0.19 0.244
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.
Petit et al. (2012)
2 more

3 mentions without citation

The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Lei et al. (2021)
2 more