› 3ry5

X-ray diffraction
2.3Å resolution

Three-dimensional structure of glycosylated fcgammariia (high-responder polymorphism)

Released:
DOI: 10.2210/pdb3ry5/pdb
PDB entry 3ry5 coloured by chain, front view.
PDB entry 3ry5 coloured by chain, side view.
PDB entry 3ry5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Fc gammaRIIa recognition of human IgG and formation of inflammatory signaling complexes.
Ramsland PA, Farrugia W, Bradford TM, Sardjono CT, Esparon S, Trist HM, Powell MS, Tan PS, Cendron AC, Wines BD, Scott AM, Hogarth PM
J Immunol 187 3208-17 (2011)
PMID: 21856937

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin gamma Fc region receptor II-a Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12318 (Residues: 37-206; Coverage: 60%)
Gene names: CD32, FCG2, FCGR2A, FCGR2A1, IGFR2
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 50.036Å b: 77.935Å c: 88.104Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

30 review citations

IgG subclasses and allotypes: from structure to effector functions.
Vidarsson et al. (2014)
29 more

3 mentions without citation

Considerations of Antibody Geometric Constraints on NK Cell Antibody Dependent Cellular Cytotoxicity.
Murin CD. (2020)
2 more