› 3s1k

X-ray diffraction
2.55Å resolution

The Development of Peptide-based Tools for the Analysis of Angiogenesis

Released:
DOI: 10.2210/pdb3s1k/pdb
PDB entry 3s1k coloured by chain, front view.
PDB entry 3s1k coloured by chain, side view.
PDB entry 3s1k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The development of peptide-based tools for the analysis of angiogenesis.
Fedorova A, Zobel K, Gill HS, Ogasawara A, Flores JE, Tinianow JN, Vanderbilt AN, Wu P, Meng YG, Williams SP, Wiesmann C, Murray J, Marik J, Deshayes K
Chem Biol 18 839-45 (2011)
PMID: 21802005

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147436 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Z-domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 59 amino acids
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulin FC, subunit C
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 102 amino acids
Theoretical weight: 11.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 214-315; Coverage: 26%)
Gene names: VEGF, VEGFA
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 69.228Å b: 72.76Å c: 76.344Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.271
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

6 review citations

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
5 more

5 mentions without citation

Systematic Targeting of Protein-Protein Interactions.
Modell et al. (2016)
4 more