› 3s84

X-ray diffraction
2.4Å resolution

Dimeric apoA-IV

Released:
DOI: 10.2210/pdb3s84/pdb
PDB entry 3s84 coloured by chain, front view.
PDB entry 3s84 coloured by chain, side view.
PDB entry 3s84 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.
Deng X, Morris J, Dressmen J, Tubb MR, Tso P, Jerome WG, Davidson WS, Thompson TB
Structure 20 767-79 (2012)
PMID: 22579246

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein A-IV Chains: A, B
Molecule details ›
Chains: A, B
Length: 273 amino acids
Theoretical weight: 31.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06727 (Residues: 84-355; Coverage: 72%)
Gene name: APOA4
Sequence domains: Apolipoprotein A1/A4/E domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6122
Unit cell:
a: 70.825Å b: 70.825Å c: 512.383Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.229
Expression system: Escherichia coli

Quick links

Citations

5 review citations

New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism.
Phillips MC. (2013)
4 more

14 mentions without citation

Pleiotropic roles of late embryogenesis abundant proteins of Deinococcus radiodurans against oxidation and desiccation.
Liu et al. (2021)
13 more