› 3s8z

X-ray diffraction
2.8Å resolution

Crystal structure of LRP6-E3E4

Released:
DOI: 10.2210/pdb3s8z/pdb
PDB entry 3s8z coloured by chain, front view.
PDB entry 3s8z coloured by chain, side view.
PDB entry 3s8z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W
Nat Struct Mol Biol 18 1204-10 (2011)
PMID: 21984209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 623 amino acids
Theoretical weight: 70.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75581 (Residues: 629-1243; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 68.6Å b: 83.75Å c: 166.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.257 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

34 review citations

Wnt signaling in stem and cancer stem cells.
Holland et al. (2013)
33 more

6 mentions without citation

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Cheng et al. (2011)
5 more