Function and Biology Details
Reaction catalysed:
Fully activates human clotting factor V by a single cleavage at the 1545-Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146105 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Factor V activator RVV-V gamma
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 25.96 KDa
Source organism: Daboia siamensis
UniProt:
Structure domains: Trypsin-like serine proteases
Length: 234 amino acids
Theoretical weight: 25.96 KDa
Source organism: Daboia siamensis
UniProt:
- Canonical:
P18965 (Residues: 25-260; Coverage: 97%)
Structure domains: Trypsin-like serine proteases
Coagulation factor V light chain
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 14 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P12259 (Residues: 1561-1574; Coverage: 1%)
