› 3sd0

X-ray diffraction
2.7Å resolution

Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

Released:
DOI: 10.2210/pdb3sd0/pdb
PDB entry 3sd0 coloured by chain, front view.
PDB entry 3sd0 coloured by chain, side view.
PDB entry 3sd0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mesecar AM, Walters RL

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 350 amino acids
Theoretical weight: 39.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 35-384; Coverage: 83%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand TSK 2 x TSK
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Unit cell:
a: 88.505Å b: 96.01Å c: 124.249Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 0.254
Expression system: Spodoptera frugiperda

Quick links