› 3se6

X-ray diffraction
3.08Å resolution

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2

Released:
DOI: 10.2210/pdb3se6/pdb
PDB entry 3se6 coloured by chain, front view.
PDB entry 3se6 coloured by chain, side view.
PDB entry 3se6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.
Birtley JR, Saridakis E, Stratikos E, Mavridis IM
Biochemistry 51 286-95 (2012)
PMID: 22106953

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180096 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Endoplasmic reticulum aminopeptidase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 967 amino acids
Theoretical weight: 111.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6P179 (Residues: 1-960; Coverage: 100%)
Gene names: ERAP2, LRAP
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
4 bound ligands:
Ligand ZN 2 x ZN
Ligand LYS 2 x LYS
Ligand NAG 3 x NAG
Ligand MES 2 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21
Unit cell:
a: 74.579Å b: 134.362Å c: 128.009Å
α: 90° β: 90.71° γ: 90°
R-values:
R R work R free
0.216 0.212 0.277
Expression system: Trichoplusia ni

Quick links

Citations

20 review citations

Genetics of ankylosing spondylitis.
Robinson et al. (2014)
19 more

12 mentions without citation

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.
Stratikos et al. (2013)
11 more