› 3sgm

X-ray diffraction
1.7Å resolution

Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100

Released:
DOI: 10.2210/pdb3sgm/pdb
PDB entry 3sgm coloured by chain, front view.
PDB entry 3sgm coloured by chain, side view.
PDB entry 3sgm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic view of a toxic amyloid small oligomer.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D
Science 335 1228-31 (2012)
PMID: 22403391

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135880 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 11 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02511 (Residues: 90-100; Coverage: 6%)
Gene names: CRYA2, CRYAB, HSPB5

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
1 modified residue:
Ligand A8E 4 x A8E

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: I213
Unit cell:
a: 65.995Å b: 65.995Å c: 65.995Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.24
Expression system: Not provided

Quick links

Citations

70 review citations

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
Jucker et al. (2013)
69 more

3 mentions without citation

Atomic view of a toxic amyloid small oligomer.
Laganowsky et al. (2012)
2 more