› 3sgr

X-ray diffraction
2.17Å resolution

Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L

Released:
DOI: 10.2210/pdb3sgr/pdb
PDB entry 3sgr coloured by chain, front view.
PDB entry 3sgr coloured by chain, side view.
PDB entry 3sgr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic view of a toxic amyloid small oligomer.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D
Science 335 1228-31 (2012)
PMID: 22403391

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135880 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 25 amino acids
Theoretical weight: 2.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02511 (Residues: 90-100; Coverage: 6%)
Gene names: CRYA2, CRYAB, HSPB5

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P61
Unit cell:
a: 52.34Å b: 52.34Å c: 87.33Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.184 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

70 review citations

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
Jucker et al. (2013)
69 more

7 mentions without citation

Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.
Arbor et al. (2016)
6 more