› 3sgs

X-ray diffraction
1.7Å resolution

Amyloid-related segment of alphaB-crystallin residues 95-100

Released:
DOI: 10.2210/pdb3sgs/pdb
PDB entry 3sgs coloured by chain, front view.
PDB entry 3sgs coloured by chain, side view.
PDB entry 3sgs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic view of a toxic amyloid small oligomer.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D
Science 335 1228-31 (2012)
PMID: 22403391

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135873 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 631 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02511 (Residues: 95-100; Coverage: 3%)
Gene names: CRYA2, CRYAB, HSPB5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 4.821Å b: 19.5Å c: 21.004Å
α: 90° β: 94.23° γ: 90°
R-values:
R R work R free
0.213 0.212 0.225
Expression system: Not provided

Quick links

Citations

70 review citations

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
Jucker et al. (2013)
69 more

5 mentions without citation

Atomic view of a toxic amyloid small oligomer.
Laganowsky et al. (2012)
4 more