› 3skp

X-ray diffraction
1.7Å resolution

The structure of apo-human transferrin C-lobe with bound sulfate ions

Released:
DOI: 10.2210/pdb3skp/pdb
PDB entry 3skp coloured by chain, front view.
PDB entry 3skp coloured by chain, side view.
PDB entry 3skp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for iron piracy by pathogenic Neisseria.
Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK
Nature 483 53-8 (2012)
PMID: 22327295

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 38.02 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P02787 (Residues: 358-698; Coverage: 50%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I422
Unit cell:
a: 95.847Å b: 95.847Å c: 204.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.198
Expression system: Cricetinae

Quick links

Citations

45 review citations

Iron in infection and immunity.
Cassat et al. (2013)
44 more

2 mentions without citation

Structural basis for iron piracy by pathogenic Neisseria.
Noinaj et al. (2012)
1 more