3sku

X-ray diffraction
4Å resolution

Herpes simplex virus glycoprotein D bound to the human receptor nectin-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-172233 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 285 amino acids
Theoretical weight: 31.62 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q991M3 (Residues: 26-310; Coverage: 72%)
Sequence domains: Herpesvirus glycoprotein D/GG/GX domain
Structure domains: Glycoprotein D; Chain: A;
Nectin-1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 319 amino acids
Theoretical weight: 35.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15223 (Residues: 31-345; Coverage: 65%)
Gene names: HVEC, NECTIN1, PRR1, PVRL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P3221
Unit cell:
a: 188.003Å b: 188.003Å c: 185.004Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.266 0.287
Expression system: Spodoptera frugiperda