› 3sm9

X-ray diffraction
2.26Å resolution

Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist

Released:
DOI: 10.2210/pdb3sm9/pdb
PDB entry 3sm9 coloured by chain, front view.
PDB entry 3sm9 coloured by chain, side view.
PDB entry 3sm9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wernimont AK, Dong A, Seitova A, Crombet L, Khutoreskaya G, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Cossar D, Dobrovetsky E, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 479 amino acids
Theoretical weight: 54.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14832 (Residues: 26-504; Coverage: 56%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand SO4 5 x SO4
Ligand Z99 1 x Z99
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I222
Unit cell:
a: 83.402Å b: 98.633Å c: 203.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.227
Expression system: Spodoptera frugiperda

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