› 3sp9

X-ray diffraction
2.3Å resolution

Structural basis for iloprost as a dual PPARalpha/delta agonist

Released:
DOI: 10.2210/pdb3sp9/pdb
PDB entry 3sp9 coloured by chain, front view.
PDB entry 3sp9 coloured by chain, side view.
PDB entry 3sp9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.
Jin L, Lin S, Rong H, Zheng S, Jin S, Wang R, Li Y
J Biol Chem 286 31473-9 (2011)
PMID: 21775429

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 281 amino acids
Theoretical weight: 32.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 173-441; Coverage: 61%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand IL2 2 x IL2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 49.124Å b: 111.905Å c: 55.012Å
α: 90° β: 93.15° γ: 90°
R-values:
R R work R free
0.198 0.195 0.253
Expression system: Escherichia coli

Quick links

Citations

4 review citations

ROR nuclear receptors: structures, related diseases, and drug discovery.
Zhang et al. (2015)
3 more

7 mentions without citation

Activation of PPARĪ“: from computer modelling to biological effects.
Kahremany et al. (2015)
6 more