› 3spv

X-ray diffraction
1.3Å resolution

Crystal structure of a peptide-HLA complex

Released:
DOI: 10.2210/pdb3spv/pdb
PDB entry 3spv coloured by chain, front view.
PDB entry 3spv coloured by chain, side view.
PDB entry 3spv coloured by chain, top view.
Source organisms:
Entry authors: Gras S, Rossjohn J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135131 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Lytic switch protein BZLF1 Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 1.01 KDa
Source organism: Human herpesvirus 4 strain B95-8
Expression system: Not provided
UniProt:
  • Canonical: P03206 (Residues: 190-197; Coverage: 3%)
Gene name: BZLF1

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 50.56Å b: 81.46Å c: 110.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.219
Expression systems:
  • Escherichia coli
  • Not provided

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