› 3ssg

X-ray diffraction
2Å resolution

Structure of transthyretin L55P in complex with Zn

Released:
DOI: 10.2210/pdb3ssg/pdb
PDB entry 3ssg coloured by chain, front view.
PDB entry 3ssg coloured by chain, side view.
PDB entry 3ssg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils.
Castro-Rodrigues AF, Gales L, Saraiva MJ, Damas AM
Acta Crystallogr D Biol Crystallogr 67 1035-44 (2011)
PMID: 22120741

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CAC 1 x CAC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P42212
Unit cell:
a: 54.615Å b: 54.615Å c: 86.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.247
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The Positive Side of the Alzheimer's Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1.
Ciccone et al. (2020)
4 more