› 3stm

X-ray diffraction
2.22Å resolution

Structure of human LFABP in complex with one molecule of palmitic acid

Released:
DOI: 10.2210/pdb3stm/pdb
PDB entry 3stm coloured by chain, front view.
PDB entry 3stm coloured by chain, side view.
PDB entry 3stm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fatty acid induced remodeling within the human liver fatty acid-binding protein.
Sharma A, Sharma A
J Biol Chem 286 31924-8 (2011)
PMID: 21757748

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, liver Chain: X
Molecule details ›
Chain: X
Length: 132 amino acids
Theoretical weight: 14.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07148 (Residues: 2-127; Coverage: 99%)
Gene names: FABP1, FABPL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand PLM 1 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 30.236Å b: 57.392Å c: 74.404Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.242 0.28
Expression system: Escherichia coli

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Citations

2 review citations

Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease.
Agarwal AK. (2012)
1 more

5 mentions without citation

Fatty acid induced remodeling within the human liver fatty acid-binding protein.
Sharma et al. (2011)
4 more