› 3swv

X-ray diffraction
3Å resolution

Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) from Homo sapiens (Human), Northeast Structural Genomics Consortium target id HR5562A

Released:
DOI: 10.2210/pdb3swv/pdb
PDB entry 3swv coloured by chain, front view.
PDB entry 3swv coloured by chain, side view.
PDB entry 3swv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Seetharaman J, Su M, Forouhar F, Wang D, Janjua H, Cunningham K, Owens L, Xiao R, Liu J, Baran MC, Acton TB, Montelione GT, Hunt JF, Tong L, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6D5 (Residues: 635-836; Coverage: 11%)
Gene names: ARFGEF2, ARFGEP2, BIG2
Sequence domains: Sec7 domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A, NSLS BEAMLINE X6A
Spacegroup: P32
Unit cell:
a: 53.939Å b: 53.939Å c: 75.725Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.262
Expression system: Escherichia coli

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