› 3sxr

X-ray diffraction
2.4Å resolution

Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib

Released:
DOI: 10.2210/pdb3sxr/pdb
PDB entry 3sxr coloured by chain, front view.
PDB entry 3sxr coloured by chain, side view.
PDB entry 3sxr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.
Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CY, Gao M, Tino J, Xie D, Tebben AJ
Chem Biol Drug Des 78 739-48 (2011)
PMID: 21883956

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-156424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic tyrosine-protein kinase BMX Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 31.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51813 (Residues: 411-675; Coverage: 39%)
Gene name: BMX
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1N1 2 x 1N1
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 58.68Å b: 67.13Å c: 169.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.231
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

BMX and its role in inflammation, cardiovascular disease, and cancer.
Cenni et al. (2012)
2 more

4 mentions without citation

Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution.
Tse et al. (2015)
3 more