› 3szr

X-ray diffraction
3.5Å resolution

Crystal structure of modified nucleotide-free human MxA

Released:
DOI: 10.2210/pdb3szr/pdb
PDB entry 3szr coloured by chain, front view.
PDB entry 3szr coloured by chain, side view.
PDB entry 3szr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Gao S, von der Malsburg A, Dick A, Faelber K, Schröder GF, Haller O, Kochs G, Daumke O
Immunity 35 514-25 (2011)
PMID: 21962493

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149011 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced GTP-binding protein Mx1 Chain: A
Molecule details ›
Chain: A
Length: 608 amino acids
Theoretical weight: 69.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20591 (Residues: 33-662; Coverage: 91%)
Gene name: MX1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 156.82Å b: 134.08Å c: 58.1Å
α: 90° β: 106.34° γ: 90°
R-values:
R R work R free
0.263 0.262 0.295
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

31 review citations

Dynamin, a membrane-remodelling GTPase.
Ferguson et al. (2012)
30 more

27 mentions without citation

Mx proteins: antiviral gatekeepers that restrain the uninvited.
Verhelst et al. (2013)
26 more