› 3t1i

X-ray diffraction
3Å resolution

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

Released:
DOI: 10.2210/pdb3t1i/pdb
PDB entry 3t1i coloured by chain, front view.
PDB entry 3t1i coloured by chain, side view.
PDB entry 3t1i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human Mre11: understanding tumorigenic mutations.
Park YB, Chae J, Kim YC, Cho Y
Structure 19 1591-602 (2011)
PMID: 22078559

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156104 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Double-strand break repair protein MRE11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 431 amino acids
Theoretical weight: 49.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49959 (Residues: 1-411; Coverage: 58%)
Gene names: HNGS1, MRE11, MRE11A
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MN 8 x MN
Ligand DTT 2 x DTT
Ligand GOL 15 x GOL
1 modified residue:
Ligand MSE 44 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 134.79Å b: 135.21Å c: 135.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.25
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.
Tsutakawa et al. (2014)
14 more

17 mentions without citation

Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.
Shin et al. (2014)
16 more