› 3t1p

X-ray diffraction
3.9Å resolution

Crystal structure of an alpha-1-antitrypsin trimer

Released:
DOI: 10.2210/pdb3t1p/pdb
PDB entry 3t1p coloured by chain, front view.
PDB entry 3t1p coloured by chain, side view.
PDB entry 3t1p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
Yamasaki M, Sendall TJ, Pearce MC, Whisstock JC, Huntington JA
EMBO Rep 12 1011-7 (2011)
PMID: 21909074

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 41.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 48-418; Coverage: 94%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P4132
Unit cell:
a: 163.691Å b: 163.691Å c: 163.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.231 0.297
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Update of the human and mouse SERPIN gene superfamily.
Heit et al. (2013)
18 more

6 mentions without citation

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
Yamasaki et al. (2011)
5 more