› 3t1w

X-ray diffraction
2.4Å resolution

Structure of the four-domain fragment Fn7B89 of oncofetal fibronectin

Released:
DOI: 10.2210/pdb3t1w/pdb
PDB entry 3t1w coloured by chain, front view.
PDB entry 3t1w coloured by chain, side view.
PDB entry 3t1w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein.
Schiefner A, Gebauer M, Skerra A
J Biol Chem 287 17578-17588 (2012)
PMID: 22442152

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ugl-Y3 Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 40.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02751 (Residues: 1173-1539; Coverage: 15%)
Gene names: FN, FN1
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 211.98Å b: 29.115Å c: 82.241Å
α: 90° β: 111.42° γ: 90°
R-values:
R R work R free
0.23 0.228 0.277
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.
Urbanski et al. (2018)
5 more

7 mentions without citation

"Protein" no longer means what it used to.
Parisi et al. (2021)
6 more