› 3t3q

X-ray diffraction
2.1Å resolution

Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine

Released:
DOI: 10.2210/pdb3t3q/pdb
PDB entry 3t3q coloured by chain, front view.
PDB entry 3t3q coloured by chain, side view.
PDB entry 3t3q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.
DeVore NM, Meneely KM, Bart AG, Stephens ES, Battaile KP, Scott EE
FEBS J 279 1621-31 (2012)
PMID: 22051186

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2A6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 476 amino acids
Theoretical weight: 54.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11509 (Residues: 29-494; Coverage: 94%)
Gene names: CYP2A3, CYP2A6
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand 9PL 4 x 9PL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 70.952Å b: 159.836Å c: 103.855Å
α: 90° β: 91.79° γ: 90°
R-values:
R R work R free
0.214 0.211 0.257
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structural diversity of eukaryotic membrane cytochrome p450s.
Johnson et al. (2013)
4 more

3 mentions without citation

Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis
Elfaki et al. (2018)
2 more