› 3tjq

X-ray diffraction
2Å resolution

N-domain of HtrA1

Released:
DOI: 10.2210/pdb3tjq/pdb
PDB entry 3tjq coloured by chain, front view.
PDB entry 3tjq coloured by chain, side view.
PDB entry 3tjq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of HtrA1 and its subdomains.
Eigenbrot C, Ultsch M, Lipari MT, Moran P, Lin SJ, Ganesan R, Quan C, Tom J, Sandoval W, van Lookeren Campagne M, Kirchhofer D
Structure 20 1040-50 (2012)
PMID: 22578544

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease HTRA1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92743 (Residues: 7-7, 35-156; Coverage: 23%)
Gene names: HTRA, HTRA1, PRSS11
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand PT 2 x PT
Ligand CL 6 x CL
Ligand SCN 4 x SCN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P3121
Unit cell:
a: 72.085Å b: 72.085Å c: 41.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.217 0.27
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

The emerging roles of HTRA1 in musculoskeletal disease.
Tiaden et al. (2013)
8 more

7 mentions without citation

Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery.
Chen et al. (2020)
6 more