› 3tkp

X-ray diffraction
2.49Å resolution

Crystal structure of full-length human peroxiredoxin 4 in the reduced form

Released:
DOI: 10.2210/pdb3tkp/pdb
PDB entry 3tkp coloured by chain, front view.
PDB entry 3tkp coloured by chain, side view.
PDB entry 3tkp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4.
Wang X, Wang L, Wang X, Sun F, Wang CC
Biochem J 441 113-8 (2012)
PMID: 21916849

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-4 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 246 amino acids
Theoretical weight: 28.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13162 (Residues: 38-271; Coverage: 100%)
Gene name: PRDX4
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 183.149Å b: 141.12Å c: 61.295Å
α: 90° β: 103.08° γ: 90°
R-values:
R R work R free
0.215 0.18 0.222
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone.
Wang et al. (2015)
22 more

7 mentions without citation

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.
Bolduc et al. (2021)
6 more