› 3tkq

X-ray diffraction
2.22Å resolution

Crystal structure of full-length human peroxiredoxin 4 with mixed conformation

Released:
DOI: 10.2210/pdb3tkq/pdb
PDB entry 3tkq coloured by chain, front view.
PDB entry 3tkq coloured by chain, side view.
PDB entry 3tkq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4.
Wang X, Wang L, Wang X, Sun F, Wang CC
Biochem J 441 113-8 (2012)
PMID: 21916849

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-4 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 246 amino acids
Theoretical weight: 28.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13162 (Residues: 38-271; Coverage: 100%)
Gene name: PRDX4
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: C2
Unit cell:
a: 108.486Å b: 139.518Å c: 96.197Å
α: 90° β: 103.38° γ: 90°
R-values:
R R work R free
0.213 0.186 0.224
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone.
Wang et al. (2015)
22 more

3 mentions without citation

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.
Bolduc et al. (2021)
2 more